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+At the base of the channel is the methyltransfer pore, which connects the pocket to the AdoMet-binding cleft. In both proteins, the walls of the lysine-binding channel are fashioned by hydrophobic residues that engage in van der Waals interactions with the lysine aspect chain (Determine 4b,c ).
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+Min J, Zhang X, Cheng X, Grewal SI, Xu RM: Structure of the SET area histone lysine methyltransferase Clr4.
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